JOURNAL ARTICLE
A protein-conjugated photosensitizer with mitochondrial targeting for enhanced photodynamic therapy
Mingwan ShiWei PanPeng GaoYuanyuan ChenKaiye WangNa LiBo Tang
Year: 2022 Journal: Chemical Communications Vol: 58 (83)Pages: 11729-11732 Publisher: Royal Society of Chemistry
Abstract
A protein-conjugated photosensitizer with mitochondrial targeting was synthesized for enhanced photodynamic therapy. In vitro and in vivo experiments demonstrated that the produced ROS induced mitochondria-mediated cell apoptosis.
Keywords:
Photosensitizer Photodynamic therapy Conjugated system Chemistry Mitochondrion Biophysics Photochemistry Cancer research Medicine Biochemistry Biology Organic chemistry
Metrics
13
Cited By
1.60
FWCI (Field Weighted Citation Impact)
21
Refs
0.77
Citation Normalized Percentile
Is in top 1%
Is in top 10%
Citation History
Topics
ATP Synthase and ATPases Research
Life Sciences → Biochemistry, Genetics and Molecular Biology → Molecular Biology
Nanoplatforms for cancer theranostics
Physical Sciences → Engineering → Biomedical Engineering
Cancer, Hypoxia, and Metabolism
Life Sciences → Biochemistry, Genetics and Molecular Biology → Cancer Research
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