Metal−Organic Frameworks as Sensors of Biomolecules

Abstract

Metal-organic framework (MOF), a novel hybrid porous material which is bridged by the metal center and organic linkers, has become a promising candidate in biosensing applications due to their superior properties. Many types of MOFs were applied for sensing biomacromolecules (nucleic acid, enzyme/protein) and small biomolecules (dopamine, amino acid, glucose, and H2O2). Herein, the unique properties of MOF, such as rational aperture design, diversity, easy to functionalize, high Brunauer-Emmett-Teller (BET)/Langmuir surface area, etc., have been highlighted and the relationships between properties and detection performances have been discussed. Meanwhile, an update of MOF for biosensing has been provided.