α–Catenin-dependent vinculin recruitment to adherens junctions is antagonistic to focal adhesions
Vidal Bejar-PadillaJolene I. CabeSantiago LópezVani NarayananMazen MezherVenkat MaruthamuthuDaniel E. Conway
Abstract
Vinculin is a mechanosensitive protein found at both focal adhesions (FAs) and adherens junctions (AJs). Recruitment of vinculin to AJs results in impaired FA formation, occurring as a result of a structural rearrangement of the actin cytoskeleton. Vinculin translocation between AJs and FAs is necessary for efficient collective cell migration.
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