Antibacterial and wound healing efficacy of Chromolaena odorata treated dressings

Abstract

This paper reports the characteristics of viscose fabric treated with the extracts of Chromolaena odorata, traditionally used for healing the wounds. C. odorata extracts (5%) are nano-sprayed and applied on spun lace viscose fabric using an ultrasonic atomiser and antibacterial competence is optimised for S. aureus and E. coli. The wound healing potential of the C. odorata treated dressing and histopathological analysis of the wound tissues have been studied in vivo on Albino Wistar rats and compared with wound without any dressings, chitosan treated dressing, chitosan and C. odorata treated dressing along with the commercial silver bandage. The FTIR analysis of the phytochemicals finished fabric indicates the presence of phenolic group. Cytotoxicity test reveals 22% cytotoxicity and 78% cell viability with mild toxicity. Shelf life discloses the decrease in antibacterial efficiency after third and fourth week. Curing of C. odorata extracts treated fabric inversely affects the antibacterial efficiency, and sterilisation reports 46.7% E.coli reduction after one hour. The fabricated wound dressings are found to have good wound healing efficiency as compared to commercial silver bandage. The histopathological analysis reveals complete healing of wounds after 21 post wound healing days. The study proves that the phytochemicals can be imparted on spun lace viscose fabric for antibacterial and wound healing application to a certain period of time.