Structure-activity relationship studies on divalent naphthalene diimide G quadruplex ligands with anticancer and antiparasitic activity

Manuel Pérez-Soto; Pablo Peñalver; Steven T. G. Street; Dora Weenink; Michael O’Hagan; Javier Ramos‐Soriano; Yi‐Fan Jiang; Gregory J. Hollingworth; M. Carmen Galán; Juan Carlos Morales

doi:10.1016/j.bmc.2022.116946

JOURNAL ARTICLE

Structure-activity relationship studies on divalent naphthalene diimide G quadruplex ligands with anticancer and antiparasitic activity

Manuel Pérez-Soto Pablo Peñalver Steven T. G. Street Dora Weenink Michael O’Hagan Javier Ramos‐Soriano Yi‐Fan Jiang Gregory J. Hollingworth M. Carmen Galán Juan Carlos Morales

Year: 2022 Journal: Bioorganic & Medicinal Chemistry Vol: 71 Pages: 116946-116946 Publisher: Elsevier BV

DOI: 10.1016/j.bmc.2022.116946

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Keywords:

Chemistry Antiparasitic Stereochemistry Structure–activity relationship Ligand (biochemistry) Antiparasitic agent Trypanosoma brucei Selectivity Biological activity Lead compound In vitro Biochemistry Pharmacology Receptor

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DNA and Nucleic Acid Chemistry

Life Sciences → Biochemistry, Genetics and Molecular Biology → Molecular Biology

Advanced biosensing and bioanalysis techniques

Life Sciences → Biochemistry, Genetics and Molecular Biology → Molecular Biology

HIV/AIDS drug development and treatment

Health Sciences → Medicine → Infectious Diseases

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