Determination of paracetamol using screen-printed carbon electrode

Abstract

A sensitive and selective electrochemical sensor based on screen-printed carbon electrode (SPCE) for detecting paracetamol has been studied. The SPCE performance was observed using cyclic voltammetry (CV) in 0.1 M phosphate buffer solution at various pH. The measurement was done at a potential range from -0.75 V to +1 V at room temperature. The response of SPCE shows that paracetamol can be detected clearly from its oxidation (0.63 V) and reduction (-0.36 V) peaks in 0.1 M phosphate buffer solution at pH 9. The obtained calibration curve followed a linear equation ipa = 3.159 + 0.134x, with R2 = 0.975 for anodic current peak and ipc = -3.373 – 0.102x, with R2 = 0.990 for cathodic current peak. The limit of detection (LOD) of the SPCE to detect paracetamol was 0.70 µM and 0.51 µM for oxidation and reduction peaks, respectively. The sensitivity of SPCE was 2.628 μA.mm-2.μM-1 for oxidation peak and 1.996 μA.mm-2.μM-1 for reduction peak. The reaction between the SPCE and paracetamol demonstrated diffusion-controlled behavior. The selectivity study indicates no interference signal from ascorbic acid, urea, uric acid, and glucose during paracetamol measurement.