Acid-Responsive Multifunctional Zeolitic Imidazolate Framework-8 (ZIF-8) Nanocomposites for Tumor Chemo-Photothermal Synergistic Therapy

Abstract

Camptothecin (CPT), a broad-spectrum anticancer drug, has been extensively used clinically. However, its hydrophobic properties seriously hinder its antitumor therapeutic effect. Herein, we synthesized acid-degradable Fe₃O₄@poly(vinylpyrrolidone) (Fe₃O₄@PVP)/gold nanoclusters@zeolitic imidazolate framework-8 composite nanoparticles (ZIF-8CNPs) via a facile method and utilized them as carriers to efficiently load CPT. The excellent fluorescence properties of gold nanoclusters (AuNCs) and the photothermal properties of Fe₃O₄@poly(vinylpyrrolidone) (Fe₃O₄@PVP) endowed the nanocomposites with excellent cell imaging and photothermal functions. In addition, the surface modification of the composite nanoparticles with folic acid-grafted bovine serum albumin (FA-BSA) enables them to efficiently target tumor cells. Once FA-BSA/ZIF-8CNPs-CPT are taken up by tumor cells and irradiated with a near-infrared laser, the nanoparticles show a highly effective inhibitory effect against various tumor cells through a chemo-photothermal synergistic effect. Hence, it is conceivable that this acid-responsive multifunctional ZIF-8 nanocomposite has promising bioapplication prospects in cancer treatment.