pH‐Responsive Pt@mSiO₂@CaP Core–Shell Nanoplatforms for Synergistic Chemo‐ and Photothermal Therapy

Abstract

Abstract Platinum/mesoporous silica/amorphous calcium phosphate core–shell nanoplatforms (Pt@mSiO 2 @CaP) are prepared for near‐infrared light‐triggered photothermal therapy and pH‐responsive chemotherapy. In the core–shell nanoplatforms, the Pt cores with flower‐like shapes exhibit broadband near‐infrared light absorption, which endows the nanoplatforms with a remarkable photothermal performance under 808 nm laser irradiation. The mesoporous SiO 2 intermediate layers offer accessible channels for drug loading. The drug release from the SiO 2 intermediate layers is driven by the acidic environment of tumor cells owing to the biodegradability of the CaP outermost layer. The hyperthermia generated by the Pt cores accelerates the drug release, thereby increasing intracellular drug concentration. A marked synergistic therapeutic effect of chemo‐ and photothermal therapy in vitro is demonstrated using the DOX‐loaded Pt@mSiO 2 @CaP. The design of the three‐layer core–shell nanoplatforms points out a way to the synthesis of multifunctional nanomaterials and extends to theranostic applications.