Synthesis and Structure Determination of 2-Cyano-3-(1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl)acrylamide

Benson M. Kariuki; Bakr F. Abdel-Wahab; Hanan A. Mohamed; Gamal A. El‐Hiti

doi:10.3390/m1372

ScienceGate Book Chapters

JOURNAL ARTICLE

Synthesis and Structure Determination of 2-Cyano-3-(1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl)acrylamide

Benson M. Kariuki Bakr F. Abdel-Wahab Hanan A. Mohamed Gamal A. El‐Hiti

Year: 2022 Journal: Molbank Vol: 2022 (2)Pages: M1372-M1372 Publisher: Multidisciplinary Digital Publishing Institute

DOI: 10.3390/m1372

Get Full-Text PDF Get Analytical Report

Abstract

2-Cyano-3-(1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl)acrylamide (3) was synthesized in 90% yield from condensation of equimolar equivalents of 1-phenyl-3-(thiophen-2-yl)-1H-pyrazole-4-carbaldehyde (1) and 2-cyanoacetamide (2) in boiling ethanol under basic condition for 45 min. The structure of 3 was determined using NMR spectroscopy and single crystal X-ray diffraction.

Keywords:

Chemistry Acrylamide Cyanoacetamide Pyrazole Yield (engineering) Ethanol Proton NMR Condensation Boiling Medicinal chemistry Condensation reaction Nuclear magnetic resonance spectroscopy Crystal structure Nuclear chemistry Organic chemistry Catalysis Polymer

Metrics

Cited By

0.52

FWCI (Field Weighted Citation Impact)

Refs

0.50

Citation Normalized Percentile

Is in top 1%

Is in top 10%

Citation History

Topics

Synthesis and biological activity

Physical Sciences → Chemistry → Organic Chemistry

Multicomponent Synthesis of Heterocycles

Physical Sciences → Chemistry → Organic Chemistry

Synthesis of heterocyclic compounds

Physical Sciences → Chemistry → Organic Chemistry

Synthesis and Structure Determination of 2-Cyano-3-(1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl)acrylamide

Abstract

Metrics

Citation History

Topics

Related Documents

SYNTHESIS, CHARACTERIZATION OF SOME 1-(2-HYDROXY-PHENYL)-3-(1-PHENYL-3-THIOPHEN-2-YL-1H-PYRAZOL-4-YL)-PROPENONE, 3-CHLORO-2-(1-PHENYL-3-THIOPHEN-2-YL-1H-PYRAZOL-4-YL)-CHROMON-4-ONE AND 2-(1'-PHENYL-3'-THIOPHEN-2-YL-3,4-DIHYDRO-2H,1H'-[3,4]BIPYRAZOL-5-YL)-PHENOL

SYNTHESIS AND CHARACTERISATION OF SOME 2-[2(1-PHENYL-3-THIOPHEN-2-YL-1H-PYRAZOL-4-YL)]-VINYL CHROMENE-4-ONES

(2E)-3-(3-Methoxy-1-phenyl-1H-pyrazol-4-yl)-2-propenal