Electrochemical Studies of Meropenem at Glassy Carbon Electrode and its Direct Determination in Human Plasma by Square Wave Anodic Adsorptive Stripping Voltammetry

Abstract

In present study a sensitive and fast square wave anodic adsorptive stripping voltammetric method was developed for the trace analysis of antibacterial drug meropenem in human plasma at glassy carbon electrode.The oxidation of meropenem gave a well-defined peak in Britton Robinson buffer at glassy carbon electrode.The process was diffusion controlled.A linear response was obtained between 1.0x10 -7 to 4.0x10 -5 M in aqueous media.The recovery studies were also achieved to check sensitivity and accuracy of the method.The proposed method was applied for the determination of meropenem in body fluids without any time-consuming extraction, separation, adsorption steps.The value of limit of detection (LOD) for human urine and human serum samples was found to be 2.27x10 -6 M and 1.67x10 -6 M respectively.