Dissolved oxygen scavenging by acoustic droplet vaporization using intravascular ultrasound

Abstract

Modification of dissolved gas content by nucleation of acoustic droplet vaporization (ADV) has been proposed for several therapeutic applications. Reducing dissolved oxygen could inhibit reactive oxygen species production during reperfusion of ischemic tissue, such as during coronary interventions to rescue myocardium. Localization of the effect may be achieved using intravascular ultrasound (IVUS), commonly used to image the coronaries in such patients. The objective of this study was to determine whether IVUS can be used to reduce dissolved oxygen by ADV.