Selective Determination of Uric Acid by Using a β-Cyclodextrin Modified Electrode

Abstract

A β-cyclodextrin (CD) modified poly(N-acetylaniline) (PNAANI) glassy carbon electrode (GCE) was used to study the electrode reaction of uric acid (UA). The formation of a supramolecular complex between β-CD and UA improves the sensitivity and selectivity of the UA determination. The mechanism of selective detection of UA at the β-CD/PNAANI/GCE is proposed. Also, an analytical procedure involving square-wave voltammetry has been developed for determination of UA in the concentration range 1.0×10−5 to 2.0×10−4 mol dm−3.