Pharmacokinetic/pharmacodynamic modelling in pre-clinical drug discovery

Abstract

One of the most important aspects of drug metabolism/pharmacokinetics in drug development is to show that the animals used in toxicology have been exposed to the same chemical species (drug and metabolites) as will your patient. Usually the metabolism and kinetics of the drug are studied in animals with radiolabelled compound and the quickest way of getting the comparative information from man is also to give a radioactive dose.