DNA-Binding Ligands from Peptide Libraries Containing Unnatural Amino Acids

Theo Lescrinier; Chris Hendrix; Luc Kerremans; Jef Rozenski; Andreas Link; Bart Samyn; Arthur Van Aerschot; Eveline Lescrinier; Ramón Eritja; Jozef Van Beeumen; Piet Herdewijn

doi:10.1002/(sici)1521-3765(19980310)4:3<425::aid-chem425>3.3.co;2-n

JOURNAL ARTICLE

DNA-Binding Ligands from Peptide Libraries Containing Unnatural Amino Acids

Theo Lescrinier Chris Hendrix Luc Kerremans Jef Rozenski Andreas Link Bart Samyn Arthur Van Aerschot Eveline Lescrinier Ramón Eritja Jozef Van Beeumen Piet Herdewijn

Year: 1998 Journal: Chemistry - A European Journal Vol: 4 (3)Pages: 425-433 Publisher: Wiley

DOI: 10.1002/(sici)1521-3765(19980310)4:3<425::aid-chem425>3.3.co;2-n

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Abstract

Combinatorial chemistry with a newly-developed screening procedure using complementary fluorescein- and rhodamine-labelled oligonucleotides (below) has been used to select peptide dsDNA binding ligands. A high structure–affinity relationship of the dsDNA-binding unnatural peptide was observed.

Keywords:

Peptide Oligonucleotide Chemistry Rhodamine Combinatorial chemistry DNA Fluorescein Stereochemistry Biochemistry Fluorescence

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DNA-Binding Ligands from Peptide Libraries Containing Unnatural Amino Acids

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