Sensitive ultraviolet spectrophotometric determination of quetiapine fumarate in pharmaceuticals

Abstract

Quetiapine fumarate (QTF) is a psychotropic agent belonging to the chemical class of benzisoxazole derivatives indicated for the treatment of schizophrenia.It is a selective monoaminergic antagonist with high affinity for the serotonin type 2 (5HT2), and dopamine type 2 (□ 2) receptors.Two simple, sensitive, selective, economical and reproducible u v spectrophotometric methods are described for the quantitative determination of QTF in bulk drug and เท pharmaceutical dosage forms.The methods are based on measurement of absorbance of QTF solution either in 0.1 N HCI at 209 nm (method A) or in methanol at 208 nm (method B).Beer's law is obeyed over the linear range 1.25-12.50|Tg ml_"1 QTF for both the methods with apparent molar absorptivity values of 6.21 X 104 and 5.93 X 104 L mol'1 cm"1 for method A and method B, respectively.Sandell sensitivity, limits of quantification (LOQ) and detection (LOD) are also reported.The methods were validated in accordance with the current ICH guidelines.The precision results, expressed by intra-day and inter-day relative standard deviation values, are satisfactory (RSD < 2.50%).The accuracy is also satisfactory (RE < 2.50%).Excipients used as additives in pharmaceutical formulations did not interfere in the proposed procedures as shown by the recovery study via standard addition technique with percentage recoveries in the range 101.50-108.25% with the standard deviation of < 1.12%.