Lipid peroxidation and antioxidant system status in rheumatoid arthritis patients

Abstract

Recently, there has been significantly increased interest in the study of the role of free-radical lipid oxidation reactions in the development of the pathological process in rheumatoid arthritis. Immune complexes formed in this disease are a stimulus for neutrophil chemotaxis and initiation of phagocytosis reactions. The process of phagocytosis, accompanied by the release of a large number of reactive oxygen radicals, leads to damage of neutrophils themselves, release of lysosomal enzymes, degradation of collagen, hyaluronic acid and to connective tissue damage.