Preliminary Studies of Fe(BDC) Metal-Organic Framework (MOF) as a Non-Enzymatic Glucose Detection

Abstract

Diabetes is one of fatal diseases, which is caused by the high glucose level in the blood. Nowadays, diabetes has become a serious health problem that millions of people all over the world suffer from it. Therefore, the development of glucose monitoring system is highly demanded. Many studies on the glucose detection are carried out based on the non-enzymatic system due to their modification flexibility and easiness in preparation. In this work, the non-enzymatic glucose detection was conducted based on the electrochemical biosensor, i.e. metal-organic framework (MOF)-modified glassy carbon electrode (GCE). The MOF material consisted of ferrite (Fe) as the metal ion and terephthalic acid (H2BDC) as the ligand, which in short was defined as Fe(BDC) MOF. The material characterization and biosensing performance evaluation were conducted using scanning electron microscopy (SEM) and cyclic voltammetry (CV) method, respectively. The SEM result showed that Fe(BDC) MOF had an octahedral structure. Furthermore, from the CV diagram, it showed that the Fe(BDC) MOF had a distinct response to glucose with a peak current of the reduction and the oxidation were 1.8 μA and 1.4 μA, respectively. These results, indicated that Fe(BDC) MOF has a promising potential to be used as an electrochemical biosensor, especially for glucose detection.