Plant Mediated Synthesis of Titanium Dioxide Nanoparticles for Burn Wound Management

The burn wound is one of the most common and devastating forms of

trauma, which places a significant burden on healthcare systems. Wound healing is a

complex process that helps re-establish the integrity of the damaged tissue. Natural

products have been shown to possess anti-inflammatory, antimicrobial, pro-collagen

synthesis and cell-stimulating properties, which contribute to the accelerated healing

process. These natural products possess wound healing properties of mixtures of

compounds with synergistic or additive effects; therefore their applications are limited

when they are used as a single compound. However, nanotechnology is a promising

powerful tool in drug delivery, which is attributed to their stability, high loading

capacity, and targeted delivery. The main objective of this chapter is to provide updated

information on the plant-mediated synthesis of titanium dioxide nanoparticles for burn

wound management. This chapter explains the plant-mediated synthesis of titanium

dioxide nanoparticles for burn wound management, their potential therapeutic effects,

focus on synthesis, plant-based, applications and mechanism of action in different

phases of wound healing. Also, it provided the literature reports available on various in

vitro and in vivo studies on the use of plant titanium dioxide nanoparticles for wound

healing. Pharmaceutical nanotechnologies are an innovation used for regenerative

medicine in the near future and proved efficient in managing burn wounds.