Our results suggest that ERO1α acts as a thiol oxidase for Ca2+ signaling molecules, STIM1 and SERCA2, and enhances cytosolic Ca2+ levels, promoting platelet activation and aggregation. Our study provides evidence that ERO1α may be a potential target to reduce thrombotic events.
Alethele Oliveira SantosMaria Célia DelduqueSandra Mara Campos Alves
Luiz Eduardo Dado CherenPaulo Márcio CruzFlávio RamosEmanuela Cristina Andrade LacerdaAna Selma MoreiraFernando Laélio Coelho
Francisco Hurtado DelgadoClaudia Itzel González Fuentes