Nanoparticles breakthroughs tumor treatment limitations by regulating tumor immune microenvironment to enhance tumor immunotherapy efficacy

Abstract

After recent years of tumor treatment research, scientists gradually found that immunotherapy has the best application prospect among various treatment methods. Immunotherapy can be achieved through the external adjustment of the patient's immune system to achieve the optimal “self-healing” method, avoiding the difficulty of medication due to individual differences and complex personalized treatment formulation. The conversion of the complex tumor immune microenvironment (TME) is the most representative research hotspot in immunotherapy. Nanoparticles can target or adjust specific parts of TME effectively, which not only can improve the therapeutic effect but also have an important role in tumor recovery and metastasis. In this article, we systematically summarized nanoparticles regulate TME to enhance tumor immunotherapy efficacy.