SYNTHESIS AND ANTIBACTERIAL EVALUATION OF CERTAIN 1,2,4- TRIAZOLE AND THIAZOLID INONE DERIVATIVES

Abstract

The synthesis of certain 3 -  (4- chloro - 3,5 - đimethyl - phenoxy ) methyl  4-alkyl or aryl -5 mercapto - 1,2,4 - triazoles ( 5a - e) is described. The preparation of these triazoles was achieved by the cyclization of the corresponding thiosemicarbazides (Af- i) using piperidine in refluxing ethanol. Also , series of thioethers (6a,b) and (7a-g) were obtained by reacting (5) with different halo- compounds .The thiaz olidinone derivatives (8 a - d ) were prepared by reacting (4f - j) with ethyl bromoacetate .The new compounds were proved by elemental analysis, ir and 1H- nmr. The antibacterial activity was carried out for eight representative compounds .