Phytochemical investigation and Antipyretic activity of Tectona grandis Linn.

Abstract

Tectona grandis is having an incredible utilizations in the timber industry, also enjoys extensive appositeness in traditional and folklore medicine. Teak, the whole tree holds profuse of pharmacological properties with less exposure on the seeds. the present work is to extract and isolate the secondary metabolites from the methanolic extract by column chromatography followed by acute toxicity and antipyretic activity in adult Wistar rats. A dose of 200mg/kg methanolic seed extract was selected as a dose based on the acute toxicity study. Yeast induced antipyretic model in rats was employed for antipyretic activity. Five compounds were isolated from the methanolic seed extract and which are reported for the first time from the seeds. The structures were established by detailed spectral analysis using Mass, IR, and 1H NMR. The extract showed significant antipyretic activity in rats when compared to the respective standard drugs.