Simulating drug concentrations in PDMS microfluidic organ chips

Jennifer Grant; Aliçan Özkan; Crystal Yuri Oh; Gautam Mahajan; Rachelle Prantil‐Baun; Donald E. Ingber

doi:10.1039/d1lc00348h

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Simulating drug concentrations in PDMS microfluidic organ chips

Jennifer Grant Aliçan Özkan Crystal Yuri Oh Gautam Mahajan Rachelle Prantil‐Baun Donald E. Ingber

Year: 2021 Journal: Lab on a Chip Vol: 21 (18)Pages: 3509-3519 Publisher: Royal Society of Chemistry

DOI: 10.1039/d1lc00348h

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Abstract

A simulation method for predicting drug responses is described that overcomes challenges relating to absorption of hydrophobic drug molecules by Organ Chips made from polydimethylsiloxane (PDMS).

Keywords:

Polydimethylsiloxane Microfluidics Drug Nanotechnology Materials science Absorption (acoustics) Pharmacology Medicine Composite material

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3D Printing in Biomedical Research

Physical Sciences → Engineering → Biomedical Engineering

Innovative Microfluidic and Catalytic Techniques Innovation

Physical Sciences → Engineering → Biomedical Engineering

Microfluidic and Capillary Electrophoresis Applications

Physical Sciences → Engineering → Biomedical Engineering

Simulating drug concentrations in PDMS microfluidic organ chips

Abstract

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Citation History

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