JOURNAL ARTICLE
Relaxed initiation pausing of ribosomes drives oncogenic translation
L. DongYuanhui MaoAidong ZhouXiaomin LiuJun ZhouJi WanShu‐Bing Qian
Year: 2021 Journal: Science Advances Vol: 7 (8) Publisher: American Association for the Advancement of Science
Abstract
Ribosome pausing at start codons limits translational output, which is controlled by altered mRNA methylation in cancer cells.
Keywords:
Ribosome Translation (biology) Messenger RNA Ribosome profiling Biology Methylation Translational regulation Cell biology Eukaryotic translation Initiation factor Internal ribosome entry site Protein biosynthesis Computational biology EIF4E Genetics RNA Gene
Metrics
16
Cited By
1.17
FWCI (Field Weighted Citation Impact)
62
Refs
0.74
Citation Normalized Percentile
Is in top 1%
Is in top 10%
Citation History
Topics
RNA modifications and cancer
Life Sciences → Biochemistry, Genetics and Molecular Biology → Molecular Biology
RNA and protein synthesis mechanisms
Life Sciences → Biochemistry, Genetics and Molecular Biology → Molecular Biology
Cancer-related molecular mechanisms research
Life Sciences → Biochemistry, Genetics and Molecular Biology → Cancer Research
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