JOURNAL ARTICLE

AI3SD Video: Drug Repositioning for COVID-19

John P. Overington

Year: 2020 Journal:   ePrints Soton (University of Southampton)   Publisher: University of Southampton

Abstract

Pandemics, such as Covid-19. are by definition essentially unanticipatable and rapid onset. Features unfortunately incompatible with current industry capabilities in drug discovery. This has led to a large number of studies, both theoretical and experimental to reposition, or reuse an existing drug for Covid-19 therapy. There are some general patterns of success in historical repositioning that point to the most likely strategies for drug repositioning, and also, following some specific data gathering and curation, to point towards specific actionable activities for Covid-19. The presentation will briefly overview drug repositioning as a general strategy, and then the focussed application of core concepts towards the treatment of Covid-19.

Keywords:
Drug repositioning Coronavirus disease 2019 (COVID-19) Pandemic Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 2019-20 coronavirus outbreak Presentation (obstetrics) Reuse Computer science Drug Data science Medicine Engineering Virology Pharmacology Infectious disease (medical specialty) Disease

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Topics

Computational Drug Discovery Methods
Physical Sciences →  Computer Science →  Computational Theory and Mathematics
COVID-19 Clinical Research Studies
Health Sciences →  Medicine →  Infectious Diseases
Pharmacological Receptor Mechanisms and Effects
Life Sciences →  Biochemistry, Genetics and Molecular Biology →  Molecular Biology
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