Immune Response In Various Diffuse Parenchymal Lung Disorders (DPLDs)

Abstract

Lung has one of the largest surface areas. It has to bear the brunt of infinite insults both from the airway and vascular end. The inhaled particles depending upon the size are cleared either by the luminal or the alveolar or the interstitial macrophages. The alveolar and interstitial macrophages clear the engulfed particles via the lymphatic system, which depends upon the blood perfusion. Most of the particles from the lower and middle lobes are cleared successfully, but the particle engulfed by macrophages in the upper lobe get trapped in the interstitium because of poor lymphatic supply.