2-D Bi₂O₂Se Nanosheets for Nonenzymatic Electrochemical Detection of H₂O₂

Abstract

Bismuth oxyselenide (Bi ₂ O ₂ Se) has recently emerged as a promising 2-D material for high-performance electronic and optoelectronic applications. However, its true potential is yet to be explored for chemical sensing applications. The present investigation highlights the first demonstration of a Bi ₂ O ₂ Se nanosheets-based sensor for nonenzymatic electrochemical detection of hydrogen peroxide (H ₂ O ₂ ). A solution-phase method is employed to synthesize Bi ₂ O ₂ Se nanosheets. Cyclic voltammetry is performed to study the quantitative detection of H ₂ O ₂ with a reduction potential of -0.68 V versus Ag/AgCl in nitrogen-saturated 0.1 M PBS (pH 7.4). The Bi ₂ O ₂ Se nanosheets-based H ₂ O ₂ sensor shows efficient detection of H ₂ O ₂ in the range of 50-500 μM with a sensitivity of 100 μA mA ^-1 cm ^-2 , and negligible interference was observed for most of the common interferents such as NaCl, ascorbic acid, uric acid, and dopamine. Furthermore, the applicability of this electrochemical approach for practical applications is confirmed by the observation of concentration-dependent effect of H ₂ O ₂ on the reduction current in artificial sweat, making Bi ₂ O ₂ Se nanosheets a compelling electrocatalyst candidate for the development of new wearable glucose sensors.