Research progress of microRNAs in colorectal cancer therapy

Abstract

The molecular targeted therapy method using microRNAs (miRNAs) is gradually stepping into people's vision. miRNAs affect colorectal cancer progress via abnormal expression in tumor cells or microenvironment. The high or low expressions of miRNAs in specific tissues probably have an impact on the expressions of oncogenes, tumor suppressor genes or other aspects including the surrounding environments, the metastases and the drug tolerance of tumors, thus contributing to curing the colorectal cancer. Nowadays, miRNA has entered the stage of animal experiments. Key words: MicroRNAs; Colorectal neoplasms; Targeted therapy