Lipoprotein lipase and hepatic lipase

Abstract

Knowledge of the molecular structure and interactions of the lipases is expanding rapidly. Lipase activities are regulated by modulation of messenger RNA levels and by incompletely defined post-translational mechanisms. Evidence is growing that lipoprotein lipase acts not only as a hydrolytic enzyme, but also as a ligand that targets lipoprotein for binding to cell-surface heparan sulphate and to receptors.