Wei LiHuawei ZhuYunjiao ChenHang XiaoYazhong GeHai‐e HuXueli LiYong Cao
Abstract Phyllanthus emblica ( P. emblica ) is a traditionally edible fruit that is good for treatment of biliary diseases, bronchitis, etc. It has obvious anti‐inflammatory activity, but few studies focus on its anti‐inflammatory active substance basis. The purpose of this study was to explore the material basis of anti‐inflammatory activity of P. emblica , purify, and identify anti‐inflammatory active monomers. Fisetin and gallic acid, which were identified after separation from ethanol extract components of P. emblica , exhibited the best anti‐inflammatory effects, markedly inhibiting nitric oxide and proinflammatory cytokine levels in LPS‐stimulated macrophages. In particular, fisetin with significant anti‐inflammatory activity was firstly identified from P. emblica . For the first time, our research systematically revealed the material basis of the anti‐inflammatory effects of P. emblica from the perspective of the composition of the bioactive substances and provided scientific research methods and ideas for researching bioactive monomers in other plant extracts.
Jinhuang ShenYifan ZhangZhang LiNana YangXinhua MaTian‐Hua ZhongYonghong ZhangYong‐Hong ZhangYong‐Hong Zhang
Arja Ihantola-VormistoJari SummanenHannu KankaanrantaHeikki VuorelaZaini AsmawiEeva Moilanen
Ali ŞenSuna Özbaş TuranLeyla Bitiş
Qing LiuYa-Feng WangRong-Jie ChenMeiying ZhangYifei WangChong‐Ren YangYing‐Jun Zhang