BIOAVAILABILITY ENHANCEMENT OF POORLY-WATER SOLUBLE DRUGS BY SOLID DISPERSION

Abstract

Solubilization of poorly-water soluble drugs is most interesting field in pharmaceutical industry. Currently, up to 40% of new drug candidates have been discovered are water-insoluble drugs. Hence, they have low absorption and bioavailability. Solid dispersion, a popular technique that is currently gaining much attention from pharmaceutical scientists known to improve the solubility and dissolution rate of poorly water-soluble drugs. A number of key references that describe state-of-the-art technologies have been collected in this review, which addresses various pharmaceutical strategies for the solubilization of poorly water-soluble drugs using solid dispersion. Keywords: solid dispersion; poorly water-soluble drugs; dissolution. Key words: Solid dispersion; poorly water-soluble drugs; dissolution