Electroanalytical Sensing of Piperazine at Carbon Nanotubes/Nafion Composite-modified Glassy Carbon and Screen-printed Carbon Electrodes in Human Plasma

Abstract

Abstract: Herein, we report a simple and efficient voltammetric method for the electrochemical sensing of piperazine. This method is based on the electro-oxidation of piperazine at the carbon nanotubes (CNTs)/nafion composite-modified glassy carbon and screen-printed carbon electrodes. The modified electrodes showed an enhanced activity toward the electro-oxidation of piperazine when compared to either the CNTs-modified or nafion-modified electrodes. Linear sweep voltammetry provided a well-defined electro-oxidation peak at +1.15 V (vs. Ag/AgCl) and differential pulse voltammetry was used as a sensitive technique for piperazine determination in micro-molar amounts. Under optimized conditions, the calibration curves obtained showed the linear response range from 0.4 to 12 ?M with a detection limit of 0.11 ?M. The method was used for the determination of piperazine in human plasma samples with good recovery results. 2020, Pleiades Publishing, Ltd.