Highly sensitive glucose measurement using an amplified redox sensor

Abstract

Abstract In the detection of chemical materials, redox sensors are attractive owing to their fast response, high sensitivity, simplicity, and miniaturization. For point-of-care testing devices or in vivo sensing devices, the miniaturization of redox sensors is important. However, it also leads to a reduction of the sensing area and a decrease in the redox output current. In our research group, an amplified redox sensor (ARS) integrated with a working electrode that is connected to the base terminal of a bipolar transistor was developed. As a result of the chronoamperometry method, i.e. using the ARS coated with glucose oxidase enzyme membrane via entrapping immobilization, a current amplified by about 100 times as compared with that of a similar-sized simple electrode can be obtained in a glucose measurement. Such a small measurement system could be realized with a high-precision measurement system by amplifying the redox current via the ARS.