Square Wave Anodic Stripping Voltammetric Determination of Paracetamol at Poly Luminol/Functionalized Multi-Walled Carbon Nanotubes Modified Glassy Carbon Electrode

Abstract

In the present study an electrochemical sensor, based on glassy carbon electrode (GCE) modified by polyluminol (PLum)/functionalized multi-walled carbon nanotube (f-MWCNTs) was introduced for the determination of paracetamol. Modified electrode was made by casting the f-MWCNTs on GCE and electropolymerization of luminol on its surface. The surface morphology was investigated by scanning electron microscopy (SEM) and impedance electrochemical spectroscopy (EIS). The effective parameters on the response of the modified electrode were optimized, and the square wave anodic stripping voltammetry (SWASV) was applied for drug determination. Under the optimized conditions, at least two linear dynamic ranges (0.04–32.2 and 32.2–172.2 µM) were observed between the anodic peak currents and concentrations of PCM when PLum/f-MWCNTs/GCE was used, and its detection limit was 25 nM. The proposed electrode was successfully applied to determine PCM in pharmaceutical formulations, urine and serum samples.