GPCR-targeted drug discovery

Abstract

G-protein coupled receptors (GPCRs), also known as 7 transmembrane receptors, are the largest family of cell surface receptors. They are involved in a wide variety of physiological and pathological processes and are the largest family of druggable targets. Our group is interested in the biological functions of GPCRs and their roles in major diseases including autoimmune disease, neurodegenerative diseases, metabolic diseases and etc. In addition to the mechanism study, we also screen and develop drugs targeting GPCRs. Natural compounds may exert their effect by targeting GPCRs.