Compact Continuous Non-Invasive Blood Glucose Monitoring using Bluetooth

Abstract

A working prototype of a compact wearable affordable continuous non-invasive blood glucose measurement system based on the electromagnetic properties of glucose in blood has been implemented and demonstrated in-vivo with a Bluetooth Low Energy (BLE) based microcontroller kit. When the transmitted BLE signal is passed through the human tissue (fingertip), the proposed non-invasive measurement system uses the power level of the Received Signal Strength Indicator (RSSI) of the received BLE signal to identify the blood glucose level. The novel measurement technique for the non-invasive blood glucose monitoring using RSSI of the BLE signal, allows the prototype to be used in wearable form factor while making it affordable and reliable, something not reported in the past. Oral Glucose Tolerant Test (OGTT) have been performed on fasting human subjects by the intake of 50gm glucose solution. Concurrent measurements of the proposed non-invasive techniques and conventional invasive blood pricking were executed for correlation. The temporal trend observed on OGTT protocol from the proposed non-invasive measurement and the invasing blood pricking strongly correlates, validating the clinical significance of the proposed affordable and wearable prototype.