MOF‐Derived Spinel NiCo₂O₄ Hollow Nanocages for the Construction of Non‐enzymatic Electrochemical Glucose Sensor

Abstract

Abstract Non‐enzymatic glucose sensor is greatly expected to take over its enzymatic counterpart in the future. In this paper, we reported on a facile strategy to construct a non‐enzymatic glucose sensor by use of NiCo 2 O 4 hollow nanocages (NiCo 2 O 4 HNCs) as catalyst, which was derived from Co‐based zeolite imidazole frame (ZIF‐67). The NiCo 2 O 4 HNCs modified glassy carbon electrode (NiCo 2 O 4 HNCs/GCE), the key component of the glucose sensor, showed highly electrochemical catalytic activity towards the oxidation of glucose in alkaline media. As a result, the proposed non‐enzymatic glucose sensor afforded excellent analytical performances assessed with the aid of cyclic voltammetry and amperometry (i–t). A wide linear range spanning from 0.18 μΜ to 5.1 mM was achieved at the NiCo 2 O 4 HNCs/GCE with a high sensitivity of 1306 μA mM −1 cm −2 and a fast response time of 1 s. The calculated limit of detection (LOD) of the sensor was as low as 27 nM (S/N=3). Furthermore, it was demonstrated that the non‐enzymatic glucose sensor showed considerable anti‐interference ability and excellent stability. The practical application of the sensor was also evaluated by determination of glucose levels in real serum samples.