JOURNAL ARTICLE
A self-assembled RNA-triple helix hydrogel drug delivery system targeting triple-negative breast cancer
Lairong DingJunwei LiChangrong WuFeng YanXuemei LiShusheng Zhang
Year: 2019 Journal: Journal of Materials Chemistry B Vol: 8 (16)Pages: 3527-3533 Publisher: Royal Society of Chemistry
Abstract
A novel RNA-triple-helix hydrogel for treatment of triple negative breast cancers (TNBCs) by incorporating RNA-triple-helix and siRNA duplexes of CXCR4 into the same RNA nanoparticles was developed, without the synthetic polycationic reagents.
Keywords:
Triple-negative breast cancer Triple helix Drug delivery Materials science Drug Breast cancer Self-healing Targeted drug delivery Cancer Helix (gastropod) Self-healing hydrogels Cancer research Nanotechnology RNA Medicine Pharmacology Chemistry Biochemistry Polymer chemistry Biology Internal medicine Stereochemistry Gene Pathology
Metrics
79
Cited By
4.33
FWCI (Field Weighted Citation Impact)
33
Refs
0.94
Citation Normalized Percentile
Is in top 1%
Is in top 10%
Citation History
Topics
RNA Interference and Gene Delivery
Life Sciences → Biochemistry, Genetics and Molecular Biology → Molecular Biology
Advanced biosensing and bioanalysis techniques
Life Sciences → Biochemistry, Genetics and Molecular Biology → Molecular Biology
DNA and Nucleic Acid Chemistry
Life Sciences → Biochemistry, Genetics and Molecular Biology → Molecular Biology
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