Assessing virus like particles formation and r-HBsAg aggregation during large scale production of recombinant hepatitis B surface antigen from Pichia pastoris

Seyed Nezamedin Hosseini; Taravat Sarvari; Ghazal Bashiri; Maryam Khatami; Seyed Abbas Shojaosadati

doi:10.1016/j.ijbiomac.2019.08.019

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Assessing virus like particles formation and r-HBsAg aggregation during large scale production of recombinant hepatitis B surface antigen from Pichia pastoris

Seyed Nezamedin Hosseini Taravat Sarvari Ghazal Bashiri Maryam Khatami Seyed Abbas Shojaosadati

Year: 2019 Journal: International Journal of Biological Macromolecules Vol: 139 Pages: 697-711 Publisher: Elsevier BV

DOI: 10.1016/j.ijbiomac.2019.08.019

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Keywords:

Pichia pastoris HBsAg Chemistry Chromatography Dynamic light scattering Recombinant DNA Hepatitis B virus Ultrafiltration (renal) Size-exclusion chromatography Virus-like particle Ion chromatography Downstream processing Affinity chromatography High-performance liquid chromatography Biochemistry Virus Virology Materials science Biology Enzyme Nanotechnology Nanoparticle

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Hepatitis B Virus Studies

Health Sciences → Medicine → Epidemiology

Viral gastroenteritis research and epidemiology

Health Sciences → Medicine → Infectious Diseases

Herpesvirus Infections and Treatments

Health Sciences → Medicine → Epidemiology

Assessing virus like particles formation and r-HBsAg aggregation during large scale production of recombinant hepatitis B surface antigen from Pichia pastoris

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