JOURNAL ARTICLE
ChemInform Abstract: Asymmetric Synthesis of Tetrahydropyridines via an Organocatalytic One‐Pot Multicomponent Michael/Aza‐Henry/Cyclization Triple Domino Reaction.
Marcus BluemelPankaj ChauhanRobert G. HahnGerhard RaabeDieter Enders
Year: 2015 Journal: ChemInform Vol: 46 (18) Publisher: Wiley
Abstract
Abstract A squaramide‐catalyzed asymmetric multicomponent Michael/aza‐Henry/cyclization triple domino reaction of 1,3‐dicarbonyl compounds, β‐nitroolefins, and imines to provide potentially bioactive tetrahydropyridines in good yields and excellent enantioselectivities is developed.
Keywords:
Squaramide Chemistry Domino Michael reaction Cascade reaction Organocatalysis Nitroaldol reaction Combinatorial chemistry Organic chemistry Catalysis Enantioselective synthesis
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Topics
Synthetic Organic Chemistry Methods
Physical Sciences → Chemistry → Organic Chemistry
Asymmetric Synthesis and Catalysis
Physical Sciences → Chemistry → Organic Chemistry
Chemical Synthesis and Analysis
Life Sciences → Biochemistry, Genetics and Molecular Biology → Molecular Biology
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