Preparation and Synthetic Applications of N-(α,β-Unsaturated Acyl)-α-amino Acid Derivatives
Alan R. KatritzkyReena GyandaNabin Kumar MeherYuming Song
Abstract
N-(α,β-Unsaturated acyl)-α-amino acids, amides and esters are structural motifs of many biologically active natural products.An alternate and advantageous approach for the synthesis of N-(α,β-unsaturated acyl)-α-amino acid derivatives is developed via acylation of unprotected α-amino acids with stable crystalline N-(α,β-unsaturated acyl)benzotriazole.The proposed methodology provides a new synthesis for compound (9) which is a precursor to a novel cytotoxic agent.
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