Facile alkylation of 2-methyl-2-oxazoline: Synthesis of novel 2-substituted-2-oxazolines

Rutger D. Puts; Dotsevi Y. Sogah

doi:10.1016/s0040-4039(00)78182-2

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Facile alkylation of 2-methyl-2-oxazoline: Synthesis of novel 2-substituted-2-oxazolines

Rutger D. Puts Dotsevi Y. Sogah

Year: 1994 Journal: Tetrahedron Letters Vol: 35 (32)Pages: 5779-5782 Publisher: Elsevier BV

DOI: 10.1016/s0040-4039(00)78182-2

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Abstract

The synthesis, mechanism of formation and purification of new oxazolines containing binaphthyl and biphenyl moieties based on alkylation of 2-methyl-2-oxazoline with alkyl halides are described. Yields up to 87 % have been realized, and the method is applicable to the syntheses of other 2-substituted-2-oxazolines.

Keywords:

Chemistry Oxazoline Alkylation Halide Alkyl Biphenyl Organic chemistry Combinatorial chemistry Catalysis

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Synthesis of heterocyclic compounds

Physical Sciences → Chemistry → Organic Chemistry

Chemical Reaction Mechanisms

Physical Sciences → Chemistry → Organic Chemistry

Coordination Chemistry and Organometallics

Physical Sciences → Chemistry → Organic Chemistry

Facile alkylation of 2-methyl-2-oxazoline: Synthesis of novel 2-substituted-2-oxazolines

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