Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis
Christopher SeymourJason KennedyShu WangChung‐Chou H. ChangCorrine F. ElliottZhongying XuScott BerryGilles ClermontGregory F. CooperHernando GómezDavid T. HuangJohn A. KellumQi MiSteven M. OpalVictor B. TalisaTom van der PollShyam VisweswaranYoram VodovotzJeremy C. WeissDonald M. YealySachin YendeDerek C. Angus
Abstract
In this retrospective analysis of data sets from patients with sepsis, 4 clinical phenotypes were identified that correlated with host-response patterns and clinical outcomes, and simulations suggested these phenotypes may help in understanding heterogeneity of treatment effects. Further research is needed to determine the utility of these phenotypes in clinical care and for informing trial design and interpretation.
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