Diffusion Tensor Imaging of Cognitive Impairment Caused by Vascular Leukoencephalus Loosening

Abstract

Aim: Diagnosis and classification of Vascular Cognitive Impairment (VCI) are still based on clinical manifestations and neuropsychological scales, but is not conducive to early clinical diagnosis and prevention.We aimed to investigate Diffusion Tensor Imaging (DTI) of cognitive impairment caused by vascular leukoencephalus loosening.Methods: Using magnetic resonance diffusion tensor imaging DTI as a research method, in combination with neuropsychological testing, we investigated the relationship between brain white matter microstructural changes and cognitive impairment in patients with cognitive impairment.Systematic analysis was performed in all 60 patients with leukoaraiosis.Results: Compared with the Normal Control (NC) group, the anisotropy fraction AF values in the Regions of Interest (ROIs) of vascular dementiaVaD patients were significantly decreased.The ADC values of the various regions of interest in vascular dementiaVaD patients were significantly higher.anisotropy fraction AF values and apparent diffusion coefficient ADC values and cognitive scores in specific white matter areas were found to be independent predictors in non-dementia vascular cognitive impairment VCIND. Conclusion:The relationship between changes in white matter microstructure and cognitive function provides the basis for clinical control and ideas for early detection, early prevention and early treatment.