JOURNAL ARTICLE
Investigation of multi-trait associations using pathway-based analysis of GWAS summary statistics
Guangsheng PeiHua SunYulin DaiXiaoming LiuZhongming ZhaoPeilin Jia
Year: 2019 Journal: BMC Genomics Vol: 20 (S1)Pages: 79-79 Publisher: BioMed Central
Abstract
Our study revealed that risk variants for 25 different traits aggregated in particular biological pathways and that these pathways were frequently shared among traits. Our results confirmed known mechanisms and also suggested several novel insights into the etiology of multi-traits.
Keywords:
Genome-wide association study Trait Biology Quantitative trait locus Genetic association Genetic architecture Summary statistics Genetics Computational biology Statistical power Statistics Gene Genotype Single-nucleotide polymorphism Computer science Mathematics
Metrics
22
Cited By
3.20
FWCI (Field Weighted Citation Impact)
54
Refs
0.92
Citation Normalized Percentile
Is in top 1%
Is in top 10%
Citation History
Topics
Genetic Associations and Epidemiology
Life Sciences → Biochemistry, Genetics and Molecular Biology → Genetics
Bioinformatics and Genomic Networks
Life Sciences → Biochemistry, Genetics and Molecular Biology → Molecular Biology
Epigenetics and DNA Methylation
Life Sciences → Biochemistry, Genetics and Molecular Biology → Molecular Biology
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