Copper/Cuprous Oxide Nanoparticles Decorated Reduced Graphene Oxide Sheets Based Platform for Bio‐Electrochemical Sensing of Dopamine

Abstract

Abstract A rudimentary simple sonochemical approach has been employed for the synthesis of copper/cuprous oxide nanoparticles (Cu/Cu 2 O NPs) decorated graphene oxide (GO) sheets. Simply, an aqueous dispersion of GO was sonochemically treated with Cu/Cu 2 O NPs as obtained through a simple electrochemical dissolution method to get the Cu/Cu 2 O/rGO nanocomposite. The decoration of Cu/Cu 2 O NPs on GO sheets resulted in the excellent sensing activity of Cu/Cu 2 O/rGO nanocomposite towards dopamine in the pharmaceutical formulation at the electrode interface due to enhanced electron mobility in GO sheet and high catalytic activity of Cu/Cu 2 O NPs. The comparison has been laid out based on various characterization techniques viz. powder X‐ray diffraction (PXRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infra‐red (FTIR) spectroscopy and Raman spectroscopy. The fabricated sensor depicted high sensitivity of 0.806 μA/μM for dopamine in a broad linear range of 0.25 –17 μM. Moreover, the remarkable detection limit of 2.6 nM was found for dopamine, and the developed sensor exhibited a wide separation ca. 140 mV between the respective detection peaks of dopamine and uric acid, which is a major interferent in the analysis of dopamine.