Alzheimer’s Disease and Natural Products

Abstract

As per the World Health Organization report, dementia will be a global burden soon.Developing countries are spending a huge amount of money for health and medical support to affected people.The prevalence of neurological diseases (e.g., Alzheimer's disease, AD) is continuing to increase worldwide due to lack of the understanding of disease etiology and the causes.AD is characterized by extracellular accumulation of aggregated amyloid-β protein, intracellular accumulation of hyper-phosphorylated tau protein, neuroinflammation, and a reduction in cerebral glucose consumption. 1 The prevalence state of this disease in developing countries are not well known or neglected due to lack of awareness, insufficient medical facilities, and religious, social and other cultural practices.Pharmaceutical companies are trying hard to develop an effective drug for AD.Since several clinical trials are underway, the complexity of the disease impedes progress in drug discovery.Now, emerging evidence suggests that insulin resistance could cause AD, which is referred to as Type-3 Diabetes. 1 There is a new strategy in place to exploit pre-approved diabetic drugs in preventing or delaying the occurrence or progression of Type-3 Diabetes like state (AD) due to the insulin resistance in brain.However, there is a bumpy road ahead in finding an effective therapeutic measure for AD.