miR-222-3p promotes osteosarcoma cell migration and invasion through targeting TIMP3

Guo Jian-ping; Quanxiang Liu; Zengxin Li; Haifeng Guo; Changshuang Bai; Fajia Wang

doi:10.2147/ott.s175745

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JOURNAL ARTICLE

miR-222-3p promotes osteosarcoma cell migration and invasion through targeting TIMP3

Guo Jian-ping Quanxiang Liu Zengxin Li Haifeng Guo Changshuang Bai Fajia Wang

Year: 2018 Journal: OncoTargets and Therapy Vol: Volume 11 Pages: 8643-8653 Publisher: Dove Medical Press

DOI: 10.2147/ott.s175745

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Abstract

Our findings constitute evidence that miR-222-3p promotes OS cell proliferation and invasion through targeting TIMP3 mRNA and provide novel insight into the mechanism underlying the development of OS.

Keywords:

Gentamicin protection assay microRNA Cell growth Downregulation and upregulation Osteosarcoma Cancer research Matrix metalloproteinase In vivo Cell culture Reporter gene Cell migration MTT assay Luciferase Cell In vitro Biology Molecular biology Chemistry Gene expression Gene Transfection Western blot Genetics

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MicroRNA in disease regulation

Life Sciences → Biochemistry, Genetics and Molecular Biology → Cancer Research

Cancer-related molecular mechanisms research

Life Sciences → Biochemistry, Genetics and Molecular Biology → Cancer Research

Circular RNAs in diseases

Life Sciences → Biochemistry, Genetics and Molecular Biology → Molecular Biology

miR-222-3p promotes osteosarcoma cell migration and invasion through targeting TIMP3

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