Cover Feature: Peroxisome‐targeted Supramolecular Nanoprobes Assembled with Pyrene‐labelled Peptide Amphiphiles (Chem. Asian J. 22/2018)

Abstract

A peroxisome-targetable supramolecular nanoprobe was developed based on the self-assembly of peptide amphiphiles (PAs) in water. The nanostructured fluorescent probe was decorated with a short tripeptide of SKL (serine-lysine-leucine)–carboxylic group (COOH), which is a well-known peroxisome-targeting signal type 1 (PTS1) recognized by the PTS receptor–Pex5p of the peroxisomal membrane. The subcellular organelle-targeting ability of the nanoprobes was affected by the presence of SKL-COOH at the C-terminus of the PA, the extent of α-helical nature of the peptide, and the fibrillar morphology of the nanostructure. More information can be found in the Communication by Eun Hee Han, Eunji Lee et al. on page 3485 in Issue 22, 2018 (DOI: 10.1002/asia.201800863).