Multi-target-directed ligands for Alzheimer's disease: Discovery of chromone-based monoamine oxidase/cholinesterase inhibitors

Joana Reis; Fernando Cagide; Martín Estrada; José Teixeira; Donatella Bagetta; Concepción Pérez; Eugenio Uriarte; Paulo J. Oliveira; Francesco Ortuso; Stefano Alcaro; Marı́a Isabel Rodrı́guez-Franco; Fernanda Borges

doi:10.1016/j.ejmech.2018.07.056

JOURNAL ARTICLE

Multi-target-directed ligands for Alzheimer's disease: Discovery of chromone-based monoamine oxidase/cholinesterase inhibitors

Joana Reis Fernando Cagide Martín Estrada José Teixeira Donatella Bagetta Concepción Pérez Eugenio Uriarte Paulo J. Oliveira Francesco Ortuso Stefano Alcaro Marı́a Isabel Rodrı́guez-Franco Fernanda Borges

Year: 2018 Journal: European Journal of Medicinal Chemistry Vol: 158 Pages: 781-800 Publisher: Elsevier BV

DOI: 10.1016/j.ejmech.2018.07.056

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Keywords:

Chromone Chemistry Monoamine oxidase Cholinesterase IC50 Bifunctional Stereochemistry Lead compound Drug discovery Combinatorial chemistry Pharmacology Enzyme Biochemistry In vitro

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Citation History

Topics

Cholinesterase and Neurodegenerative Diseases

Health Sciences → Medicine → Pharmacology

Computational Drug Discovery Methods

Physical Sciences → Computer Science → Computational Theory and Mathematics

Synthesis and biological activity

Physical Sciences → Chemistry → Organic Chemistry

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